1、Nomenclature

English name：Mycophenolate Mofetil (MMF) 

2、Structural formula

Molecular formula：C₂₃H₃₁NO₇        
Molecular mass：433.50       
CAS No.： 128794-94-5

3、Mechanism and clinical use:

Mycophenolate Mofetil synthesized by macaulophenic acid and morpholine ethanol is a novel immunosuppressant against purine metabolism. It is used to prevent rejection after kidney transplantation and to treat acute rejection and refractory rejection after transplantation.

Mycophenolate mofetil has a stronger inhibitory effect on EB virus induced B lymphocyte blast transformation.

(1) When used in combination with other immunosuppressive agents, it increases the risk of lymphoma and other malignant tumors (especially skin cancer), and excessive suppression of the immune system may also increase the chance of infection.

(2) The plasma concentration of MPA did not change significantly when acyclovir or ganciclovir was combined with acyclovir. In contrast, patients with impaired renal function had increased concentrations of acyclovir or ganciclovir when combined.

(3) Sulfopyrazone may interfere with the secretion of sulfopyrazone from renal tubules, and the toxicity of sulfopyrazone may increase when combined with sulfopyrazone.

(4) With magnesium or aluminum containing antacids (such as magnesium hydroxide, aluminum hydroxide), absorption of the drug is reduced.

(5) Echinacea can stimulate the immune system, which may reduce the efficacy of the drug.

(6) Iron can reduce the absorption of the drug and decrease its efficacy.

(7) The efficacy of the drug may be reduced by concomitant use with drugs that can interfere with the enterohepatic circulation, such as cholestyamin.

(8) The possibility of changing the pharmacokinetic parameters of oral contraceptives after long-term use of this drug cannot be excluded. This may lead to reduced efficacy of oral c

4、Executive standards
CP

5、Qualification certificate
Register 'A' status; Domestic GMP; WC License

6、Packaging size specification

Inner package: double-layers polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 20 kg/drum